Chinese Premier Li Keqiang called for increased production and supply of low-cost domestic medicines for leukemia patients following reports saying the drug has been unavailable for months, a government website reported on Monday.

Mercaptopurine tablets, a potent medication used for some types of acute leukemia in combination with other drugs has been unavailable at pharmacies across China.

Many Chinese patients have had to get the needed drug overseas. The Global Times found patients started looking for new sources of the medication on China's social media platforms as early as January.

Mercaptopurine tablets usually cost only 40 yuan ($6.03) a bottle but many patients have had to spend up to 170 yuan from alternative sources.

"It is another heavy blow to the families suffering from leukemia," the Chinese premier said. "Related departments should take effective measures to increase the drug supply," he said, according to a statement released by State Council website, gov.cn, on Monday.

There were six pharmaceutical companies qualified to manufacture the medicine in China, four of them stopped production years ago and two others suspended production earlier this year.

A shortage of raw materials and low profits are the main reason the companies stopped making the tablets, news site thepaper.cn reported.

Heeding the premier's call, Zhejiang Zhebei Pharmaceutical Corporation told the Global Times on Tuesday, it has already restarted making the drug. A first batch of 2.95 million tablets is ready for deliver and more mercaptopurine tablets will be produced in accordance with market demand, an employee surnamed Tan said.

Production was ramped up after the company's newly built warehouse received government approval on November 17, Tan said.

"Government departments quickened the approval process for the new warehouse. It usually takes a long time," he added.

The other company, Shaanxi Xingbang Pharmaceutical Corporation, still hasn't started production due to a shortage of raw materials, thepaper.cn reported.

Acute shortages of drugs are not only a worry for leukemia patients. According to a survey by Saibailan, a Beijing-based medical think tank, more than 850 drugs were listed as "short of supply" between January and May.

Supply mechanism needed

About 130 prescription drugs are occasionally in short supply, according toNational Health and Family Planning Commission, Zeng Yixin, the head of the commission told the Xinhua News Agency.

"Shortages in drug supplies have been a long-term problem in China. It's partly because of an inadequate national medical supply mechanism," Song Ruilin, executive president of the China Pharmaceutical Industry Research and Development Association, told the Global Times on Tuesday.

A complete national supple chain - from approval to production to delivery - will fundamentally solve drug supply shortages. Once a looming drug shortage is identified, medical organizations and governments should respond quickly through and effective reporting mechanism, Song said.

Song also called on the government to support the manufacturing of low-profit drugs to ensure pharmaceutical companies don't lose money.

In June, nine governmental organs jointly released a guideline in an effort to cope with shortages of prescription drugs, Xinhua reported. By the end of this year China will put in place mechanisms for collecting, monitoring and managing shortages of certain drugs, according to the guidelines.

"It is a good guideline for the medical industry but it lacks specific clauses and compulsory reporting to tackle drug shortages. It will take a long time to fully realize the goal," Song Hualin, an associate professor of medical law with Nankai University, told the Global Times.

Newspaper headline: Drug shortages a chronic problem